Article
TNFα G308A genotype, resilience to sleep deprivation, and the effect of caffeine on psychomotor vigilance performance in a randomized, double-blind, placebo-controlled, crossover study.
Chronobiology international - 1 Jan 2000
Skeiky Lillian, Brager Allison J, Satterfield Brieann C, Petrovick Martha, Balkin Thomas J, Capaldi Vincent F, Ratcliffe Ruthie H, Van Dongen Hans P A, Hansen Devon A
Abstract excerpt
The TNFα G308A gene polymorphism has been reported to influence performance impairment during total sleep deprivation (TSD). We investigated this effect in a randomized, double-blind, crossover laboratory study of repeated exposure to 48 h TSD with caffeine administration at different doses. In a retrospective analysis, we replicated the finding that the A allele of TNFα G308A, found in 4 of 12 study...
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