Impaired cognitive flexibility during sleep deprivation among carriers of the Brain Derived Neurotrophic Factor (BDNF) Val66Met allele.

doi:10.1016/j.bbr.2017.09.025

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Article

Impaired cognitive flexibility during sleep deprivation among carriers of the Brain Derived Neurotrophic Factor (BDNF) Val66Met allele.

Behavioural brain research - 15 Feb 2018

Grant Leilah K, Cain Sean W, Chang Anne-Marie, Saxena Richa, Czeisler Charles A, Anderson Clare

Abstract excerpt

Accumulating evidence points to a genetic contribution to explain inter-individual vulnerability to sleep deprivation. A functional polymorphism in the BDNF gene, which causes a valine (Val) to methionine (Met) amino acid substitution at Codon 66, has been associated with cognitive impairment, particularly in populations with impaired frontal functioning. We hypothesised that sleep deprivation, which affects...

Topics

Adolescent
Adult
Alleles
Attention
Brain-Derived Neurotrophic Factor
Cognition
Executive Function
Female
Genotype
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neuropsychological Tests

Polymorphism, Single Nucleotide

Polysomnography

Reaction Time

Sleep Deprivation

Stroop Test

Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 28947280
DOI: 10.1016/j.bbr.2017.09.025
PMCID: PMC5957758

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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