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Aminoacyl-tRNA Synthetases: On Anti-Synthetase Syndrome and Beyond

13 May 2022

Abstract excerpt

Anti-synthetase syndrome (ASSD) is an autoimmune disease characterized by the presence of autoantibodies targeting one of several aminoacyl t-RNA synthetases (aaRSs) along with clinical features including interstitial lung disease, myositis, Raynaud's phenomenon, arthritis, mechanic's hands, and fever. The family of aaRSs consists of highly conserved cytoplasmic and mitochondrial enzymes, one for each amino acid,...

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PMID: 35634293
DOI: 10.3389/fimmu.2022.866087

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