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Article

High-Throughput Screening for Protein Synthesis Inhibitors Targeting Aminoacyl-tRNA Synthetases.

SLAS discovery : advancing life sciences R & D - 1 Feb 2018

Kong Jiwon, Fang Pengfei, Madoux Franck, Spicer Timothy P, Scampavia Louis, Kim Sunghoon, Guo Min

Abstract excerpt

Aminoacylation has been implicated in a wide variety of cancers. Aminoacyl-tRNA synthetases (ARSs) exist in large excess in tumor cells due to their increased demand for translation, whereas most other protein-synthesis apparatuses are quantitatively limited. Among other components that constitute the translation machinery-namely, tRNA, amino acid, ATP, and ARS-ARS is the only target that can be blocked by small...

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PMID: 29020503
DOI: 10.1177/2472555217734128

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MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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