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Article

Modeling pediatric AML FLT3 mutations using CRISPR/Cas12a- mediated gene editing.

Leukemia & lymphoma - 1 Dec 2020

Rivera-Torres Natalia, Banas Kelly, Kmiec Eric B

Abstract excerpt

Clustered regularly interspaced palindromic repeats (CRISPR) with the associated (Cas) nuclease complexes have democratized genetic engineering through their precision and ease-of-use. We have applied a variation of this technology, known as CRISPR-directed mutagenesis (CDM), to reconstruct genetic profiles within the FLT3 gene of AML patients. We took advantage of the versatility of CDM and built expression...

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Identifiers

PMID: 32815753
DOI: 10.1080/10428194.2020.1805740
PMCID: PMC8822598

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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