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Identifying Targeted Therapies for CBFA2T3::GLIS2 Acute Myeloid Leukemia

2025-05-13

Abstract excerpt

<title>Abstract</title> <p> <italic>CBFA2T3::GLIS2</italic> fusion positive pediatric acute myeloid leukemia (AML) remains one of the worst prognostic AML subgroups. To uncover innovative targeted therapeutic approaches in this disease subtype we performed genome-scale CRISPR-Cas9 screening that highlighted a strong, selective dependency on <italic>JAK2</italic> compared to other types of cancer. Using a doxy...

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Literature Corpus work
c9c54625-026c-59ef-9df8-2b38210f6e6e
DOI
10.21203/rs.3.rs-6528748/v1
Open publication

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Identifying Targeted Therapies for CBFA2T3::GLIS2 Acute Myeloid LeukemiaDOI 10.21203/rs.3.rs-6528748/v1
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