Article

CBFA2T3-GLIS2 oncogenic fusion is sufficient for leukemic transformation

2021-08-12

Abstract excerpt

<title>Abstract</title> <p>Fusion oncoproteins are the initiating event in AML pathogenesis, although they are thought to require additional cooperating mutations for leukemic transformation. CBFA2T3-GLIS2 (C/G) fusion occurs exclusively in infants and is associated with highly aggressive disease<sup>1-4</sup>. Here we report that lentiviral transduction of C/G fusion is sufficient to induce malignant transformat...

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Literature Corpus work: 565a3b35-dab6-508f-9bcd-40f72017b050
DOI: 10.21203/rs.3.rs-757279/v1

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