Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MLL leukemia induction by t(9;11) chromosomal translocation in human hematopoietic stem cells using genome editing

12 Apr 2018

Abstract excerpt

Key Points Genome editing induces t(9;11) chromosomal translocations and transforms primary CD34+ human cord blood cells leading to acute leukemia. CD9 is upregulated in primary t(9;11) cells and is a useful marker for enrichment of genome-edited MLL-rearranged cells in vitro.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to CRISPR and Genetic Engineering
Share to Protein Degradation and Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29650777
DOI: 10.1182/bloodadvances.2017013748

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MLL leukemia induction by t(9;11) chromosomal translocation in human hematopoietic stem cells using genome editingPMID 29650777Read ↗

High-efficiency CRISPR induction of t(9;11) chromosomal translocations and acute leukemias in human blood stem cellsSemantic proximity Read ↗

MLL leukemia induction by genome editing of human CD34+ hematopoietic cellsSemantic proximity Read ↗

Therapeutic applications of CRISPR/Cas9 mediated targeted gene editing in acute lymphoblastic leukemia: current perspectives, future challenges, and clinical implicationsSemantic proximity Read ↗

CRISPR-Cas9-induced t(11;19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells in vivoSemantic proximity Read ↗

Inducible MLL-AF9 expression drives an AML program during human pluripotent stem cell-derived hematopoietic differentiationSemantic proximity Read ↗

MLL-AF9 leukemia stem cells: hardwired or taking cues from the microenvironment?Semantic proximity Read ↗

The high-performance technology CRISPR/Cas9 improves knowledge and management of acute myeloid leukemia.Semantic proximity Read ↗

Only Hematopoietic Stem and Progenitor Cells from Cord Blood Are Susceptible to Malignant Transformation by MLL-AF4 TranslocationsSemantic proximity Read ↗

Functional Interrogation of <i>HOXA9</i> Regulome in MLLr Leukemia via Reporter-based CRISPR/Cas9 screenSemantic proximity Read ↗

Identification of CD34+ and CD34− leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemiaSemantic proximity Read ↗

CRISPR/Cas9 technology abolishes the <i>BCR/ABL1</i> oncogene in chronic myeloid leukemia and restores normal hematopoiesisSemantic proximity Read ↗

ASXL1 mutation correction by CRISPR/Cas9 restores gene function in leukemia cells and increases survival in mouse xenografts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.