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Article

Targeting UHRF1-dependent DNA repair selectively sensitizes KRAS mutant lung cancer to chemotherapy.

Cancer letters - 28 Nov 2020

Tian Danmei, Tang Jinshan, Geng Xinran, Li Qingwen, Wang Fangfang, Zhao Huadong, Narla Goutham, Yao Xinsheng, Zhang Youwei

Abstract excerpt

Kirsten rat sarcoma virus oncogene homolog (KRAS) mutant lung cancer remains a challenge to cure and chemotherapy is the current standard treatment in the clinic. Hence, understanding molecular mechanisms underlying the sensitivity of KRAS mutant lung cancer to chemotherapy could help uncover unique strategies to treat this disease. Here we report a compound library screen and identification of cardiac glycosides...

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Identifiers

PMID: 32814087
DOI: 10.1016/j.canlet.2020.08.008
PMCID: PMC8293908

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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