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Article

Buxus alkaloid compound destabilizes mutant p53 through inhibition of the HSF1 chaperone axis.

Phytomedicine : international journal of phytotherapy and phytopharmacology - 1 Mar 2020

Wang Yu-Ling, Wu Wei, Su Yong-Nan, Ai Zhi-Peng, Mou Han-Chuan, Wan Luo-Sheng, Luo Ying, Qiu Ming-Hua, Zhang Ji-Hong

Abstract excerpt

BACKGROUND: P53 is the most frequently mutated gene in most tumour types, and the mutant p53 protein accumulates at high levels in tumours to promote tumour development and progression. Thus, targeting mutant p53 for degradation is one of the therapeutic strategies used to manage tumours that depend on mutant p53 for survival. Buxus alkaloids are traditionally used in the treatment of cardiovascular diseases. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32097779
DOI: 10.1016/j.phymed.2020.153187

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