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Article

Can't KEEP Up: UXS1 Dependency Exposes a Pyrimidine Vulnerability in KEAP1-Mutant Lung Cancer.

Cancer research - 1 Dec 2025

Yasseen Basma A, DeNicola Gina M

Abstract excerpt

Loss-of-function mutations in KEAP1 are found in more than 20% of non-small cell lung cancers. These mutations stabilize the transcription factor NRF2 to induce a battery of antioxidative and cytoprotective genes. Although NRF2 accumulation promotes cancer cell fitness, it also creates several targetable vulnerabilities. In this issue of Cancer Research, Gebru and colleagues reveal the dependency of KEAP1-mutant...

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Share to Carcinoma, Non-Small-Cell Lung
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Share to Kelch-Like ECH-Associated Protein 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41321105
DOI: 10.1158/0008-5472.CAN-25-3547

Genes

KEAP1
UXS1

Provenance

PubMed metadata and Literature Corpus relationships.

Related research

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