Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner.

doi:10.1158/1541-7786.MCR-16-0094

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Article

Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner.

Molecular cancer research : MCR - 1 Nov 2016

Jokić Mladen, Vlašić Ignacija, Rinneburger Miriam, Klümper Niklas, Spiro Judith, Vogel Wenzel, Offermann Anne, Kümpers Christiane, Fritz Christian, Schmitt Anna, Riabinska Arina, Wittersheim Maike, Michels Sebastian, Ozretić Luka, Florin Alexandra, Welcker Daniela, Akyuz Mehmet Deniz, Nowak Michael, Erkel Martin, Wolf Jürgen, Büttner Reinhard, Schumacher Björn, Thomale Jürgen, Persigehl Thorsten, Maintz David, Perner Sven, Reinhardt Hans Christian

Abstract excerpt

KRAS-mutant lung adenocarcinoma is among the most common cancer entities and, in advanced stages, typically displays poor prognosis due to acquired resistance against chemotherapy, which is still largely based on cisplatin-containing combination regimens. Mechanisms of cisplatin resistance have been extensively investigated, and ERCC1 has emerged as a key player due to its central role in the repair of...

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Identifiers

PMID: 27514406
DOI: 10.1158/1541-7786.MCR-16-0094

Genes

ERCC1
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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