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Article

Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in KEAP1-Mutant Lung Cancer.

Cancer research - 1 Dec 2025

Gebru Melat T, Hoffman Timothy E, Boudreau Aaron, Vu Ngoc, Han Fei, Wang Putianqi, Folk Eddie, Wu Xiumin, Newton James, Foster-Duke Kelly D, Gajda Jessica, Villa Sammy, Yang Nianxin, Sandoval Celeste M, Grant Christian, Wildeboer Samatha E, Buck Wayne R, Hickson Jonathan A, Firestone Ari J, Kort Michael, Bennett Bryson D, Shotwell J Brad, Wilson Noel S, Stokoe David

Abstract excerpt

Kelch-like ECH-associated protein 1 (KEAP1) is the third most commonly mutated gene in non-small cell lung cancer and is associated with poor prognosis. In this study, we investigated synthetic lethal interaction genes in KEAP1-mutated cancer cells and identified a dependency on UDP-xylose synthase 1 (UXS1), which converts UDP-glucuronic acid (UDP-GlcA) to UDP-xylose in the proteoglycan synthetic pathway....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40966319
DOI: 10.1158/0008-5472.CAN-24-4887
PMCID: PMC12666321

Genes

UXS1
KEAP1
UGDH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in KEAP1-Mutant Lung Cancer.PMID 40966319Read ↗

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