Article
Pharmacological or genetic inhibition of hypoxia signaling attenuates oncogenic RAS-induced cancer phenotypes.
Disease models & mechanisms - 1 Feb 2022
Zhu Jun-Yi, Huang Xiaohu, Fu Yulong, Wang Yin, Zheng Pan, Liu Yang, Han Zhe
Abstract excerpt
Oncogenic Ras mutations are highly prevalent in hematopoietic malignancies. However, it is difficult to directly target oncogenic RAS proteins for therapeutic intervention. We have developed a Drosophila acute myeloid leukemia model induced by human KRASG12V, which exhibits a dramatic increase in myeloid-like leukemia cells. We performed both genetic and drug screens using this model. The genetic screen...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.