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Article

Chronic genotype 1 hepatitis C along with cirrhosis drives a persistent imprint in virus-specific CD8+ T cells after direct-acting antiviral therapies.

Journal of viral hepatitis - 1 Dec 2020

Perpiñán Elena, Pérez-Del-Pulgar Sofía, Londoño María-Carlota, Mariño Zoe, Lens Sabela, Leonel Thais, Bartres Concepción, García-López Mireia, Rodriguez-Tajes Sergio, Forns Xavier, Koutsoudakis George

Abstract excerpt

Chronic hepatitis C virus (HCV) infection impairs HCV CD8+ T-cell responses, while it could influence immune responses towards unrelated viruses/vaccines (e.g. cytomegalovirus, CMV, and influenza, Flu). The aim of our study was to delineate whether restoration of these virus-specific CD8+ T cells occurs after direct-acting antiviral (DAA) therapies and particularly in patients with cirrhosis. We performed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32812325
DOI: 10.1111/jvh.13370

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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