Article
Virus-specific CD8(+) T cells with type 1 or type 2 cytokine profile are related to different disease activity in chronic hepatitis C virus infection.
European journal of immunology - 1 Mar 2001
Prezzi C, Casciaro M A, Francavilla V, Schiaffella E, Finocchi L, Chircu L V, Bruno G, Sette A, Abrignani S, Barnaba V
Abstract excerpt
The present study demonstrates that the quality of the virus-specific CD8(+) T cell responses, as detected by both enzyme-linked immunospot assay and specific MHC-peptide tetramers, changed in relation to the different disease activity in chronically hepatitis C virus-infected patients. Indeed, both the serum alanine transaminase and the hepatic flogosis levels were related directly to the frequencies of...
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