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Article

Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization.

Gastroenterology - 1 Jun 2008

Nakamoto Nobuhiro, Kaplan David E, Coleclough Jennifer, Li Yun, Valiga Mary E, Kaminski Mary, Shaked Abraham, Olthoff Kim, Gostick Emma, Price David A, Freeman Gordon J, Wherry E John, Chang Kyong-Mi

Abstract excerpt

BACKGROUND & AIMS: The immunoinhibitory receptor programmed death-1 (PD-1) is up-regulated on dysfunctional virus-specific CD8 T cells during chronic viral infections, and blockade of PD-1/PD-ligand (PD-L) interactions can restore their function. As hepatitis C virus (HCV) persists in the liver with immune-mediated disease pathogenesis, we examined the role of PD-1/PD-L pathway in antigen-specific CD8 T-cell...

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Identifiers

PMID: 18549878
DOI: 10.1053/j.gastro.2008.02.033
PMCID: PMC2665722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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