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Article

Tetramer enrichment reveals the presence of phenotypically diverse hepatitis C virus-specific CD8+ T cells in chronic infection.

Journal of virology - 1 Jan 2015

Nitschke Katja, Flecken Tobias, Schmidt Julia, Gostick Emma, Marget Matthias, Neumann-Haefelin Christoph, Blum Hubert E, Price David A, Thimme Robert

Abstract excerpt

UNLABELLED: Virus-specific CD8(+) T cells are rarely detectable ex vivo by conventional methods during chronic hepatitis C virus (HCV) infection. In this study, however, we were able to detect and characterize HCV-specific CD8(+) T cells in all chronically HCV genotype 1a-infected, HLA-A*02:01-positive patients analyzed by performing major histocompatibility complex (MHC) class I tetramer enrichment. Two-thirds...

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Identifiers

PMID: 25320295
DOI: 10.1128/JVI.02242-14
PMCID: PMC4301109

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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