Article

R-Spondin Mimetic, SZN-043, Induced Proliferation and Expression of Wnt Target Genes, Two Impaired Features in Human Alcohol-Associated Liver Disease

2024-11-22

Abstract excerpt

<h4>ABSTRACT</h4> Liver regeneration is impaired in patients suffering from alcohol-associated liver (ALD) diseases. Wnt ligands and their FZD receptors are dysregulated in diseased livers. R-spondin and their receptors are known to regulate Wnt activity via the stabilization of FZD receptors. Here, we investigated the components of the Wnt and R-Spondin-signaling pathways and their activity in patients with ALD....

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Literature Corpus work: e14ea58c-bff2-5f6e-87ea-9145277b0676
DOI: 10.1101/2024.11.19.624277

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