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Hepatic stellate cells control liver zonation, size and functions via R-spondin 3

12 Mar 2025

Abstract excerpt

Abstract Hepatic stellate cells (HSCs) have a central pathogenetic role in the development of liver fibrosis. However, their fibrosis-independent and homeostatic functions remain poorly understood 1–5 . Here we demonstrate that genetic depletion of HSCs changes WNT activity and zonation of hepatocytes, leading to marked alterations in liver regeneration, cytochrome P450 metabolism and injury. We identify...

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PMID: 40074890
DOI: 10.1038/s41586-025-08677-w

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