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Article

Strength of immune selection in tumors varies with sex and age.

Nature communications - 17 Aug 2020

Castro Andrea, Pyke Rachel Marty, Zhang Xinlian, Thompson Wesley Kurt, Day Chi-Ping, Alexandrov Ludmil B, Zanetti Maurizio, Carter Hannah

Abstract excerpt

Individual MHC genotype constrains the mutational landscape during tumorigenesis. Immune checkpoint inhibition reactivates immunity against tumors that escaped immune surveillance in approximately 30% of cases. Recent studies demonstrated poorer response rates in female and younger patients. Although immune responses differ with sex and age, the role of MHC-based immune selection in this context is unknown. We...

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Identifiers

PMID: 32807809
DOI: 10.1038/s41467-020-17981-0
PMCID: PMC7431859

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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