Article

Sex-based mutational landscape confers sensitivity to checkpoint blockade immunotherapy in cutaneous melanoma

2019-12-08

Abstract excerpt

Anti-programmed cell death protein 1 (PD-1) therapy provided superior benefits in skin cutaneous melanoma (SKCM), but only a minority of patients responded. As SKCM had sex-based immunological differences, we sought to explore the potential interactions between sex and clinical responses to anti-PD-1 therapy in SKCM. We found that sex had significant effects on anti-PD-1 therapy. Tumor mutation burden (TMB) and ne...

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Literature Corpus work: bd653f36-b755-5b89-a852-bea5b3cc82a8
DOI: 10.1101/868950

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