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Article

Sex-specific differences in immunogenomic features of response to immune checkpoint blockade

3 Aug 2022

Abstract excerpt

Introduction: The magnitude of response to immune checkpoint inhibitor (ICI) therapy may be sex-dependent, as females have lower response rates and decreased survival after ICI monotherapy. The mechanisms underlying this sex dimorphism in ICI response are unknown, and may be related to sex-driven differences in the immunogenomic landscape of tumors that shape anti-tumor immune responses in the context of therapy....

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PMID: 35992816
DOI: 10.3389/fonc.2022.945798

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