Article

Deciphering cellular transcriptional alterations in Alzheimer’s disease brains

2020-04-17

Abstract excerpt

Large-scale brain bulk-RNAseq studies identified molecular pathways implicated in Alzheimer’s disease (AD), however these findings can be confounded by cellular composition changes in bulk-tissue. To identify cell intrinsic gene expression alterations of individual cell types, we designed a bioinformatics pipeline and analyzed three AD and control bulk-RNAseq datasets of temporal and dorsolateral prefrontal cortex...

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Literature Corpus work: 2a8cfb7d-b781-5599-af0d-bfb48a18783d
DOI: 10.1101/2020.04.15.041376

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