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Article

Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1.

Molecular cell - 18 Feb 2005

Li Yong, Choi Mihwa, Cavey Greg, Daugherty Jennifer, Suino Kelly, Kovach Amanda, Bingham Nathan C, Kliewer Steven A, Xu H Eric

Abstract excerpt

The orphan nuclear receptor steroidogenic factor 1 (SF-1) regulates the differentiation and function of endocrine glands. Although SF-1 is constitutively active in cell-based assays, it is not known whether this transcriptional activity is modulated by ligands. Here, we describe the 1.5 angstroms crystal structure of the SF-1 ligand binding domain in complex with an LXXLL motif from a coregulator protein. The...

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Source

Identifiers

PMID: 15721253
DOI: 10.1016/j.molcel.2005.02.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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