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Article

Retinoic acid binds to the C2-domain of protein kinase C(alpha).

Biochemistry - 29 Jul 2003

Ochoa Wendy F, Torrecillas Alejandro, Fita Ignacio, Verdaguer Nuria, Corbalán-García Senena, Gomez-Fernandez Juan C

Abstract excerpt

Protein kinase C(alpha) (PKC(alpha)) is a key enzyme regulating the physiology of cells and their growth, differentiation, and apoptosis. PKC activity is known to be modulated by all-trans retinoic acid (atRA), although neither the action mechanism nor even the possible binding to PKCs has been established. Crystals of the C2-domain of PKC(alpha), a regulatory module in the protein that binds Ca(2+) and acidic...

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Identifiers

PMID: 12873138
DOI: 10.1021/bi034713g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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