Article
Contribution of endogenous antibodies to learning deficits and astrocytosis in human P301S mutant tau transgenic mice.
Scientific reports - 14 Aug 2020
van der Hoven Julia, van Hummel Annika, Przybyla Magdalena, Asih Prita R, Gajwani Mehul, Feiten Astrid F, Ke Yazi D, Ittner Arne, van Eersel Janet, Ittner Lars M
Abstract excerpt
Antibodies have been explored extensively as a potential therapeutic for Alzheimer's disease, where amyloid-β (Aβ) peptides and the tau protein deposit in patient brains. While the major focus of antibody-based therapy development was on Aβ, arguably with limited success in clinical trials, targeting tau has become an emerging strategy, possibly extending therapies to dementias with isolated tau pathology....
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