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Article

Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement

28 Jul 2016

Abstract excerpt

The spread of tau pathology correlates with cognitive decline in Alzheimer's disease. In vitro, tau antibodies can block cell-to-cell tau spreading. Although mechanisms of anti-tau function in vivo are unknown, effector function might promote microglia-mediated clearance. In this study, we investigated whether antibody effector function is required for targeting tau. We compared efficacy in vivo and in vitro of...

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PMID: 27475227
DOI: 10.1016/j.celrep.2016.06.099

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