Article
Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser422 containing epitope on pathological tau.
Acta neuropathologica communications - 12 Jul 2018
van Ameijde Jeroen, Crespo Rosa, Janson Roosmarijn, Juraszek Jarek, Siregar Berdien, Verveen Hanneke, Sprengers Imke, Nahar Tariq, Hoozemans Jeroen J, Steinbacher Stefan, Willems Roland, Delbroek Lore, Borgers Marianne, Dockx Koen, Van Kolen Kristof, Mercken Marc, Pascual Gabriel, Koudstaal Wouter, Apetri Adrian
Abstract excerpt
Aggregation of tau protein and spreading of tau aggregates are pivotal pathological processes in a range of neurological disorders. Accumulating evidence suggests that immunotherapy targeting tau may be a viable therapeutic strategy. We have previously described the isolation of antibody CBTAU-22.1 from the memory B-cell repertoire of healthy human donors. CBTAU-22.1 was shown to specifically bind a...
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