Article
Therapeutic B-cell depletion reverses progression of Alzheimer's disease.
Nature communications - 12 Apr 2021
Kim Ki, Wang Xin, Ragonnaud Emeline, Bodogai Monica, Illouz Tomer, DeLuca Marisa, McDevitt Ross A, Gusev Fedor, Okun Eitan, Rogaev Evgeny, Biragyn Arya
Abstract excerpt
The function of B cells in Alzheimer's disease (AD) is not fully understood. While immunoglobulins that target amyloid beta (Aβ) may interfere with plaque formation and hence progression of the disease, B cells may contribute beyond merely producing immunoglobulins. Here we show that AD is associated with accumulation of activated B cells in circulation, and with infiltration of B cells into the brain parenchyma,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.