Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions.

doi:10.1371/journal.pone.0094251

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Article

Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions.

PloS one - 1 Jan 2014

Petry Franck R, Pelletier Jérôme, Bretteville Alexis, Morin Françoise, Calon Frédéric, Hébert Sébastien S, Whittington Robert A, Planel Emmanuel

Abstract excerpt

Aggregates of hyperphosphorylated tau protein are found in a group of diseases called tauopathies, which includes Alzheimer's disease. The causes and consequences of tau hyperphosphorylation are routinely investigated in laboratory animals. Mice are the models of choice as they are easily amenable to transgenic technology; consequently, their tau phosphorylation levels are frequently monitored by Western blotting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24788298
DOI: 10.1371/journal.pone.0094251
PMCID: PMC4008431

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.