Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tau‐targeting passive immunization modulates aspects of pathology in tau transgenic mice

15 Jul 2014

Abstract excerpt

Immunization is increasingly recognized as a suitable therapeutic avenue for the treatment of neurological diseases such as Alzheimer's disease and other tauopathies. Tau is a key molecular player in these conditions and therefore represents an attractive target for passive immunization approaches. We performed such an approach in two independent tau transgenic mouse models of tauopathy, K369I tau transgenic K3...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to S100 Proteins and Annexins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25041093
DOI: 10.1111/jnc.12821

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tau‐targeting passive immunization modulates aspects of pathology in tau transgenic micePMID 25041093Read ↗

Passive Immunization with Phospho-Tau Antibodies Reduces Tau Pathology and Functional Deficits in Two Distinct Mouse Tauopathy ModelsSemantic proximity Read ↗

Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau.Semantic proximity Read ↗

Vectored Intracerebral Immunization with the Anti-Tau Monoclonal Antibody PHF1 Markedly Reduces Tau Pathology in Mutant Tau Transgenic Mice.Semantic proximity Read ↗

Tau pSer396 and pSer404 Define Distinct Epitope Regions Linked to Different Antibody FunctionsSemantic proximity Read ↗

Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis.Semantic proximity Read ↗

Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach.Semantic proximity Read ↗

Highly specific and selective anti‐pS396‐tau antibody C10.2 targets seeding‐competent tauSemantic proximity Read ↗

Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model.Semantic proximity Read ↗

Passive Immunization in JNPL3 Transgenic Mice Using an Array of Phospho-Tau Specific AntibodiesSemantic proximity Read ↗

Passive immunization against phosphorylated tau improves features of Huntington's disease pathologySemantic proximity Read ↗

Proteostasis as a fundamental principle of Tau immunotherapySemantic proximity Read ↗

Tau Antibody Structure Reveals a Molecular Switch Defining a Pathological Conformation of the Tau ProteinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.