Anti-Tau Monoclonal Antibodies Derived from Soluble and Filamentous Tau Show Diverse Functional Properties in vitro and in vivo.

doi:10.3233/JAD-180404

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Anti-Tau Monoclonal Antibodies Derived from Soluble and Filamentous Tau Show Diverse Functional Properties in vitro and in vivo.

Journal of Alzheimer's disease : JAD - 1 Jan 2018

Vandermeeren Marc, Borgers Marianne, Van Kolen Kristof, Theunis Clara, Vasconcelos Bruno, Bottelbergs Astrid, Wintmolders Cindy, Daneels Guy, Willems Roland, Dockx Koen, Delbroek Lore, Marreiro André, Ver Donck Luc, Sousa Cristiano, Nanjunda Rupesh, Lacy Eilyn, Van De Casteele Tom, Van Dam Debby, De Deyn Peter Paul, Kemp John A, Malia Thomas J, Mercken Marc H

Abstract excerpt

The tau spreading hypothesis provides rationale for passive immunization with an anti-tau monoclonal antibody to block seeding by extracellular tau aggregates as a disease-modifying strategy for the treatment of Alzheimer's disease (AD) and potentially other tauopathies. As the biochemical and biophysical properties of the tau species responsible for the spatio-temporal sequences of seeding events are poorly...

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PMID: 30040731
DOI: 10.3233/JAD-180404

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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