Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.

Diabetologia - 1 Dec 2007

Schäfer S A, Tschritter O, Machicao F, Thamer C, Stefan N, Gallwitz B, Holst J J, Dekker J M, 't Hart L M, t'Hart L M, Nijpels G, van Haeften T W, Häring H U, Fritsche A

Abstract excerpt

AIMS/HYPOTHESIS: Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes and reduced insulin secretion. The transcription factor TCF7L2 is an essential factor for glucagon-like peptide-1 (GLP-1) secretion from intestinal L cells. We studied whether a defect in the enteroinsular axis contributes to impaired insulin secretion in carriers of TCF7L2 polymorphisms. METHODS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arginine
Share to Glucagon-Like Peptide 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucose Clamp Technique

Share to Glucose Intolerance

Share to Glucose Tolerance Test

Share to Insulin Secretion

Share to TCF Transcription Factors

Share to Transcription Factor 7-Like 2 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 17661009
DOI: 10.1007/s00125-007-0753-6
PMCID: PMC2063563

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.PMID 17661009Read ↗

The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men.Semantic proximity Read ↗

Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test.Semantic proximity Read ↗

Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion.Semantic proximity Read ↗

TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action.Semantic proximity Read ↗

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.Semantic proximity Read ↗

Polymorphism in the Transcription Factor 7-Like 2 (TCF7L2) Gene Is Associated With Reduced Insulin Secretion in Nondiabetic WomenSemantic proximity Read ↗

A Reduced Incretin Effect Mediated by the rs7903146 Variant in the TCF7L2 Gene Is an Early Marker of β-Cell Dysfunction in Obese Youth.Semantic proximity Read ↗

TCF7L2 genetic defect and type 2 diabetes.Semantic proximity Read ↗

Potential role of TCF7L2 gene variants on cardiac sympathetic/parasympathetic activity.Semantic proximity Read ↗

A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population.Semantic proximity Read ↗

Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals.Semantic proximity Read ↗

Association of TCF7L2 allelic variations with gastric function, satiation, and GLP-1 levels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.