Article
Stochastic Epigenetic Mutations Are Associated with Risk of Breast Cancer, Lung Cancer, and Mature B-cell Neoplasms.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Oct 2020
Gagliardi Amedeo, Dugué Pierre-Antoine, Nøst Therese H, Southey Melissa C, Buchanan Daniel D, Schmidt Daniel F, Makalic Enes, Hodge Allison M, English Dallas R, Doo Nicole W, Hopper John L, Severi Gianluca, Baglietto Laura, Naccarati Alessio, Tarallo Sonia, Pace Luigia, Krogh Vittorio, Palli Domenico, Panico Salvatore, Sacerdote Carlotta, Tumino Rosario, Lund Eiliv, Giles Graham G, Pardini Barbara, Sandanger Torkjel M, Milne Roger L, Vineis Paolo, Polidoro Silvia, Fiorito Giovanni
Abstract excerpt
BACKGROUND: Age-related epigenetic dysregulations are associated with several diseases, including cancer. The number of stochastic epigenetic mutations (SEM) has been suggested as a biomarker of life-course accumulation of exposure-related DNA damage; however, the predictive role of SEMs in cancer has seldom been investigated. METHODS: A SEM, at a given CpG site, was defined as an extreme outlier of DNA...
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