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Epigenetic variability in cells of normal cytology is associated with the risk of future morphological transformation

27 Mar 2012

Abstract excerpt

BACKGROUND: Recently, it has been proposed that epigenetic variation may contribute to the risk of complex genetic diseases like cancer. We aimed to demonstrate that epigenetic changes in normal cells, collected years in advance of the first signs of morphological transformation, can predict the risk of such transformation. METHODS: We analyzed DNA methylation (DNAm) profiles of over 27,000 CpGs in cytologically...

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PMID: 22453031
DOI: 10.1186/gm323

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