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Article

Quantification of tumour evolution and heterogeneity via Bayesian epiallele detection.

BMC bioinformatics - 25 Jul 2017

Barrett James E, Feber Andrew, Herrero Javier, Tanic Miljana, Wilson Gareth A, Swanton Charles, Beck Stephan

Abstract excerpt

BACKGROUND: Epigenetic heterogeneity within a tumour can play an important role in tumour evolution and the emergence of resistance to treatment. It is increasingly recognised that the study of DNA methylation (DNAm) patterns along the genome - so-called 'epialleles' - offers greater insight into epigenetic dynamics than conventional analyses which examine DNAm marks individually. RESULTS: We have developed a...

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Identifiers

PMID: 28743252
DOI: 10.1186/s12859-017-1753-2
PMCID: PMC5526259

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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