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Article

Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines

12 Aug 2020

Abstract excerpt

BACKGROUND: Statins are widely prescribed to lower plasma low-density lipoprotein cholesterol levels. Though statins reduce cardiovascular disease risk overall, statin efficacy varies, and some people experience adverse side effects while on statin treatment. Statins also have pleiotropic effects not directly related to their cholesterol-lowering properties, but the mechanisms are not well understood. To identify...

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PMID: 32787775
DOI: 10.1186/s12864-020-06966-4

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