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Article

Identifying genetic modulators of statin response using subject-derived lymphoblastoid cell lines.

Pharmacogenomics - 1 May 2021

Kuang Yu-Lin, Theusch Elizabeth, M Krauss Ronald, W Medina Marisa

Abstract excerpt

Although statins (3-hydroxy-3-methylglutaryl-CoA reductase inhibitors) have proven effective in reducing plasma low-density lipoprotein levels and risk of cardiovascular disease, their lipid lowering efficacy is highly variable among individuals. Furthermore, statin treatment carries a small but significant risk of adverse effects, most notably myopathy and new onset diabetes. Hence, identification of biomarkers...

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Identifiers

PMID: 33858191
DOI: 10.2217/pgs-2020-0197
PMCID: PMC8115385

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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