Article
Analysis of Hepatitis B Virus Haplotype Diversity Detects Striking Sequence Conservation Across Genotypes and Chronic Disease Phase.
Hepatology (Baltimore, Md.) - 1 May 2021
Wagner Josef, Yuen Lilly, Littlejohn Margaret, Sozzi Vitina, Jackson Kathy, Suri Vithika, Tan Susanna, Feierbach Becket, Gaggar Anuj, Marcellin Patrick, Buti Ferret Maria, Janssen Harry L A, Gane Ed, Chan Henry L Y, Colledge Danni, Rosenberg Gillian, Bayliss Julianne, Howden Benjamin P, Locarnini Stephen A, Wong Darren, Thompson Alexander T, Revill Peter A
Abstract excerpt
BACKGROUND AND AIMS: We conducted haplotype analysis of complete hepatitis B virus (HBV) genomes following deep sequencing from 368 patients across multiple phases of chronic hepatitis B (CHB) infection from four major genotypes (A-D), analyzing 4,110 haplotypes to identify viral variants associated with treatment outcome and disease progression. APPROACH AND RESULTS: Between 18.2% and 41.8% of nucleotides and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.