Article
Machine-learning based patient classification using Hepatitis B virus full-length genome quasispecies from Asian and European cohorts.
Scientific reports - 11 Dec 2019
Mueller-Breckenridge Alan J, Garcia-Alcalde Fernando, Wildum Steffen, Smits Saskia L, de Man Robert A, van Campenhout Margo J H, Brouwer Willem P, Niu Jianjun, Young John A T, Najera Isabel, Zhu Lina, Wu Daitze, Racek Tomas, Hundie Gadissa Bedada, Lin Yong, Boucher Charles A, van de Vijver David, Haagmans Bart L
Abstract excerpt
Chronic infection with Hepatitis B virus (HBV) is a major risk factor for the development of advanced liver disease including fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). The relative contribution of virological factors to disease progression has not been fully defined and tools aiding the deconvolution of complex patient virus profiles is an unmet clinical need. Variable viral mutant signatures...
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