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Article

Diabetes promotes invasive pancreatic cancer by increasing systemic and tumour carbonyl stress in KrasG12D/+ mice.

Journal of experimental & clinical cancer research : CR - 10 Aug 2020

Menini Stefano, Iacobini Carla, de Latouliere Luisa, Manni Isabella, Vitale Martina, Pilozzi Emanuela, Pesce Carlo, Cappello Paola, Novelli Francesco, Piaggio Giulia, Pugliese Giuseppe

Abstract excerpt

BACKGROUND: Type 1 and 2 diabetes confer an increased risk of pancreatic cancer (PaC) of similar magnitude, suggesting a common mechanism. The recent finding that PaC incidence increases linearly with increasing fasting glucose levels supports a central role for hyperglycaemia, which is known to cause carbonyl stress and advanced glycation end-product (AGE) accumulation through increased glycolytic activity and...

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Share to Diabetes Complications
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycation End Products, Advanced

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Share to Pancreatic Neoplasms

Share to Proto-Oncogene Proteins p21(ras)

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Source

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Identifiers

PMID: 32778157
DOI: 10.1186/s13046-020-01665-0
PMCID: PMC7418209

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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