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Article

Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer

23 Jan 2020

Abstract excerpt

The TIGAR protein has antioxidant activity that supports intestinal tissue repair and adenoma development. Using a pancreatic ductal adenocarcinoma (PDAC) model, we show that reactive oxygen species (ROS) regulation by TIGAR supports premalignant tumor initiation while restricting metastasis. Increased ROS in PDAC cells drives a phenotypic switch that increases migration, invasion, and metastatic capacity. This...

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PMID: 31983610
DOI: 10.1016/j.ccell.2019.12.012

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