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Article

Hereditary chronic pancreatitis induced plasticity cooperates with mutant Kras in early pancreatic carcinogenesis.

Gut - 7 Apr 2026

Inamdar Tanvi Vikrant, Krannich Ferdinand, Hesselbarth Nico, Verma Atul, Vauti Teresa, Jasaszwili Mariami Helena, El Kassem Ghanem, Hillmer Jasmine, Kaune Tom, Boettcher Michael, Regel Ivonne, Griesmann Heidi, Esposito Irene, Glaß Markus, Hämmerle Monika, Michl Patrick, Laumen Helmut, Rosendahl Jonas

Abstract excerpt

BACKGROUND: Chronic pancreatitis (CP) is a risk factor for pancreatic cancer, with inherited cases conferring a markedly increased risk. The underlying mechanisms driving malignant transformation by CP remain poorly understood. OBJECTIVE: Combining a recently developed mouse model of CP carrying the human carboxypeptidase A1 (CPA1) p.N256K mutation with the established KrasG12D pancreatic cancer model, we...

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Share to Acinar Cells
Share to Carcinogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to Disease Models, Animal

Share to Metaplasia

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Share to Pancreatitis, Chronic

Share to Proto-Oncogene Proteins p21(ras)

Source

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Identifiers

PMID: 41419303
DOI: 10.1136/gutjnl-2025-335947
PMCID: PMC13151493

Genes

CP
CPA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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