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Article

ER stress protein AGR2 precedes and is involved in the regulation of pancreatic cancer initiation

12 Dec 2016

Abstract excerpt

The mechanisms of initiation of pancreatic ductal adenocarcinoma (PDAC) are still largely unknown. In the present study, we analysed the role of anterior gradient-2 (AGR2) in the earliest stages of pancreatic neoplasia. Immunohistochemical analysis of chronic pancreatitis (CP) and peritumoral areas in PDAC tissues showed that AGR2 was present in tubular complexes (TC) and early pancreatic intraepithelial...

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Share to Endoplasmic Reticulum Stress and Disease
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PMID: 27941872
DOI: 10.1038/onc.2016.459

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