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Article

Hyperglycemia enhances pancreatic cancer progression accompanied by elevations in phosphorylated STAT3 and MYC levels.

PloS one - 1 Jan 2020

Sato Katsuhiko, Hikita Hayato, Myojin Yuta, Fukumoto Kenji, Murai Kazuhiro, Sakane Sadatsugu, Tamura Takeshi, Yamai Takuo, Nozaki Yasutoshi, Yoshioka Teppei, Kodama Takahiro, Shigekawa Minoru, Sakamori Ryotaro, Tatsumi Tomohide, Takehara Tetsuo

Abstract excerpt

Diabetes mellitus is a well-known risk factor for pancreatic cancer. We focused on hyperglycemia, a main feature of diabetes mellitus, and uncovered its effect on precancerous pancreatic intraepithelial neoplasia (PanIN) progression. In vivo induction of hyperglycemia with 100 mg/kg streptozotocin in KrasLSL G12D Pdx1Cre (KP) mice promoted the PanIN formation and progression. Preconditioning with a high- or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32609742
DOI: 10.1371/journal.pone.0235573
PMCID: PMC7329089

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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