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A cross-cohort computational framework to trace tumor tissue-of-origin based on RNA sequencing

16 Sept 2023

Abstract excerpt

Carcinoma of unknown primary (CUP) is a type of metastatic cancer with tissue-of-origin (TOO) unidentifiable by traditional methods. CUP patients typically have poor prognosis but therapy targeting the original cancer tissue can significantly improve patients' prognosis. Thus, it's critical to develop accurate computational methods to infer cancer TOO. While qPCR or microarray-based methods are effective in...

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PMID: 37717102
DOI: 10.1038/s41598-023-42465-8

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