Article
Juvenile OLFM4-null mice are protected from sepsis.
American journal of physiology. Renal physiology - 1 Mar 2020
Stark Julie E, Opoka Amy M, Mallela Jaya, Devarajan Prasad, Ma Qing, Levinsky Nick C, Stringer Keith F, Wong Hector R, Alder Matthew N
Abstract excerpt
Pediatric sepsis is a leading cause of morbidity and mortality in children. One of the most common and devastating morbidities is sepsis-related acute kidney injury (AKI). AKI was traditionally thought to be related to low perfusion and acute tubular necrosis. However, little acute tubular necrosis can be found following septic AKI, and little is known about the mechanism of septic AKI. Olfactomedin-4 (OLFM4) is...
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