Article
Beyond cholesterol metabolism: The pleiotropic effects of proprotein convertase subtilisin/kexin type 9 (PCSK9). Genetics, mutations, expression, and perspective for long-term inhibition.
BioFactors (Oxford, England) - 1 May 2020
Cesaro Arturo, Bianconi Vanessa, Gragnano Felice, Moscarella Elisabetta, Fimiani Fabio, Monda Emanuele, Scudiero Olga, Limongelli Giuseppe, Pirro Matteo, Calabrò Paolo
Abstract excerpt
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has a crucial role in lipid metabolism, particularly due to its function in low-density lipoprotein receptor degradation. Gain-of-function genetic mutations of PCSK9 result in autosomal dominant familial hypercholesterolemia, characterized by high levels of low-density lipoprotein cholesterol (LDL-C) and clinical signs of early atherosclerosis. In recent...
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