Article
Clinicopathological and molecular analyses of linearly expanded epithelial cells with β-catenin alterations, "β-catenin signature", in the normal fallopian tube.
Histopathology - 1 Dec 2020
Koyama Kei, Maeda Daichi, Kito Masahiko, Tamura Daisuke, Kudo-Asabe Yukitsugu, Katoh Hiroto, Ishikawa Shumpei, Nanjo Hiroshi, Terada Yukihiro, Goto Akiteru
Abstract excerpt
AIMS: Recent advances in next-generation sequencing have made it clear that clonal expansion of cells harbouring driver gene mutations occurs in physiologically normal epithelium. Molecular analysis of tubal epithelium has been almost exclusively confined to the TP53 pathway, which is involved in serous carcinogenesis. Other oncogenic events have not been explored in detail. Here, we report the linear expansion...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.